Method for assembling a physiological signal monitoring device

ABSTRACT

A method for assembling a physiological signal monitoring apparatus on a body surface of a living body is provided, wherein the physiological signal monitoring apparatus is used to measure a physiological signal and includes a sensor module and a transmitter. The method comprises steps of: (a) detaching the bottom cover from the housing to expose the sticker from the bottom opening; (b) while holding the housing, causing the adhesive pad to be attached to the body surface; (c) applying a pressing force on the housing to cause the sensor module to be detached from the implantation module and the signal sensing end to be implanted under the body surface; (d) removing the implanting device while leaving the sensor module on the body surface; and (e) placing the transmitter on the base so that the signal output end is electrically connected to the port.

CROSS-REFERENCE TO RELATED APPLICATION AND CLAIM OF PRIORITY

The application claims the benefit of U.S. Provisional PatentApplication No. 62/882,140 filed on Aug. 2, 2019 and Taiwan PatentApplication No. 109100992 filed on Jan. 10, 2020, which are fullyincorporated by reference as if fully set forth.

FIELD OF THE INVENTION

The present invention is related to an operating method, and moreparticularly to a method for assembling a physiological signalmonitoring device on the body surface of a living body.

BACKGROUND OF THE INVENTION

Chronic diseases such as diabetes or chronic cardiovascular diseases aremore common than ever in the world due to the life style of peopleliving in urban areas. Because of this, certain physiological parametersof those patients with chronic disease need to be routinely monitored toeffectively control their condition so as to avoid deterioration andprovide timely treatment.

However, much of the physiological data needs to be obtained through invivo methods. In addition, it is necessary to obtain multiple items ofmeasurement data each day in order to effectively do the monitoring. Inorder to avoid the patient's discomfort caused by multiple blood drawsor body fluid extraction, some skilled people in the art tend to use asmall sensing element implanted in the subcutaneous tissue for arelatively long time to match the signal processing component for fixingto the skin surface, which can be used for days. There is no need toremove, and data such as blood glucose, blood fat, cholesterolconcentration or other measurements that provide physiologicalparameters can be collected and analyzed at any time to provideimmediate physiological data monitoring. Similar concepts can also beapplicable for implanting electronic devices such as chips into the skinof animals.

This type of physiological parameter measurement device, due to thedifficulty of the manufacturing process, is traditionally made byseparately assembling the sensor and an implanter. The sensor hasreagents such as enzymes and needs to be placed in the body. Thereagents need to be moisture-proof and sterilized during manufacture,but the implanters do not need these procedures.

According to conventional methods, such as the device and methoddisclosed in U.S. Pat. No. 9,693,713, the sensor is sealed in acontainer provided with a desiccant to isolate the source of pollutionand maintain a dry sanitary condition. If the container cannot achievethe required sterilization condition, the container may further bestored in a blister shell. Before performing a physiological test, theuser may tear off the blister shell, open the airtight container,assemble the sensor at the bottom of an implanter, and finally use theimplant to place the sensor into the skin. Although the manufacturingprocess of such devices is relatively simple, the separate productionprocesses of the two devices increases the manufacturing cost. Forusers, the implanter and the sensor must be assembled together beforeusing, which is inconvenient and troublesome. Besides, in thedescriptions of the specification of US20170188912 and U.S. Pat. No.8,764,657B2, the implanter are opened by circulating manners, which havean issue of time consuming for it usually take at least one round,typically two to three rounds, to fully open it.

In addition, during the sensor implantation process, it can be basicallydivided into two steps: needle implantation and needle extraction. Ifany of these steps cannot be completed quickly, or if the steps are notcoherent, it may cause pain or discomfort to the user.

Therefore, some issues, such as how to reduce the manufacturing processsteps of the sensor and implanter while enhancing the user'sconvenience, effectively maintaining the dry condition of thephysiological parameter sensor before implantation, and allowing theimplantation in a hygienic and painless way are technical problems to besolved.

SUMMARY OF THE INVENTION

In accordance with one aspect of the present invention, a method forassembling a physiological signal monitoring apparatus on a body surfaceof a living body is provided, wherein the physiological signalmonitoring apparatus is used to measure a physiological signal andincludes a sensor module and a transmitter, the sensor module isconfigured to be disposed on the body surface by an implanting device.The sensor module includes a sensor measuring the physiological signal,and having a signal sensing end and a signal output end; a baseaccommodating the sensor; and an adhesive pad disposed under the base,and configured to attach the base on the body surface. The transmitterhas a port for receiving the physiological signal. The implanting deviceincludes a housing having a bottom opening; an implantation moduledisposed in the housing, and bearing the sensor module; and a bottomcover detachably coupled to the bottom opening. The method comprisessteps of: (a) detaching the bottom cover from the housing to expose thesticker from the bottom opening; (b) while holding the housing, causingthe adhesive pad to be attached to the body surface; (c) applying apressing force on the housing to cause the sensor module to be detachedfrom the implantation module and the signal sensing end to be implantedunder the body surface; (d) removing the implanting device while leavingthe sensor module on the body surface; and (e) placing the transmitteron the base so that the signal output end is electrically connected tothe port.

In accordance with another aspect of the present invention, a method forassembling a physiological signal monitoring apparatus on a body surfaceof a living body is disclosed, wherein the physiological signalmonitoring apparatus is used to measure a physiological signal andincludes a sensor module and a transmitter, the sensor module isconfigured to be disposed on the body surface by an implanting device.The sensor module includes a sensor measuring the physiological signal,and having a signal sensing end and a signal output end; a baseaccommodating the sensor; and an adhesive pad disposed connecting thebase, and configured to attach the base on the body surface. Thetransmitter has a port for receiving the physiological signal. Theimplanting device includes a housing having an accommodating space; animplantation module disposed in the housing, and bearing the sensormodule; and an air-tight container accommodating therein theimplantation module and forming an air-tight space. The method comprisessteps of: (a) detaching the air-tight container from the implantingdevice to expose the adhesive pad from a bottom of the implantingdevice; (b) while holding the housing, causing the adhesive pad to beattached to the body surface; (c) applying a pressing force on thehousing to cause the sensor module to be detached from the implantationmodule and cause the signal sensing end to be implanted under the bodysurface; (d) removing the implanting device while leaving the sensormodule on the body surface; and (e) placing the transmitter on the baseso that the signal output end is electrically connected to the port ofthe transmitter.

In accordance with a further aspect of the present invention, a methodfor assembling a physiological signal monitoring apparatus on a bodysurface of a living body is disclosed, wherein the physiological signalmonitoring apparatus is used to measure a physiological signal andincludes a sensor module and a transmitter. The sensor module isconfigured to be disposed on the body surface by an implanting device.The sensor module includes a sensor measuring the physiological signal,and having a signal sensing end and a signal output end; a baseaccommodating the sensor; and an adhesive pad disposed connecting thebase, for attaching the base on the body surface. The transmitter has aport for receiving the physiological signal. The implanting deviceincludes: a housing having an accommodating space; an implantationmodule disposed in the housing, and bearing the sensor module; and asealing element causing airtight the accommodating space. The methodcomprises steps of: (a) detaching the sealing element from the housingto expose the sticker from a bottom of the housing; (b) while holdingthe housing, causing the adhesive pad to be attached to the bodysurface; (c) applying a pressing force on the housing to cause thesensor module to be detached from the implantation module and cause thesignal sensing end to be implanted under the body surface; (d) removingthe implanting device while leaving the sensor module on the bodysurface; and (e) placing the transmitter on the base so that the signaloutput end is electrically connected to the port.

The novel design in the present invention can fully satisfy therequirements of reducing manufacturing cost and is convenient to use.Thus, the present invention has utility for industry.

The objectives and advantages of the present invention will become morereadily apparent to those ordinarily skilled in the art after reviewingthe following detailed descriptions and accompanying drawings, in which:

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is an assembly diagram of the air-tight and desiccating containerfor carrying a sensor and implanting the sensor into a subcutaneousportion of a living body according to an embodiment of the presentinvention;

FIG. 2A is an assembly diagram showing more details of some elementsaccording to the embodiment in FIG. 1;

FIG. 2B is a schematic diagram showing a perspective view of theimplanting device according to some embodiments of the presentinvention;

FIG. 3 is a schematic sectional view taken along the x-x direction ofone of the embodiments shown in FIG. 2B, illustrating the container in astate of storage and to be implanted;

FIG. 4 is a schematic diagram showing a sectional view taken along theline IV-IV of the embodiment illustrated in FIG. 3 or taken along they-y direction of one of the embodiments in FIG. 2B;

FIG. 5 is a schematic diagram of the embodiment shown in FIG. 1,illustrating that the bottom cover is removed and is at the stage ofbeing prepared for the implanting;

FIG. 6 is a sectional diagram taken along the line VI-VI of theembodiment illustrated in FIG. 5;

FIG. 7 is a schematic diagram of the embodiment shown in FIG. 1,illustrating that the bottom cover is removed and the implanting mayoccur in an instant while the needle has not been implanted into thesubcutaneous portion;

FIG. 8 is a sectional diagram taken along the line VIII-VIII of theembodiment illustrated in FIG. 7;

FIG. 9 is a schematic diagram of the embodiment shown in FIG. 1,illustrating that the container is at the stage right after theimplanting;

FIG. 10 is a sectional diagram taken along the line X-X of theembodiment illustrated in FIG. 9;

FIG. 11 is a schematic diagram of the embodiment shown in FIG. 1,illustrating the stage of needle extraction after the implanting;

FIG. 12 is a sectional diagram taken along the line XII-XII of theembodiment illustrated in FIG. 11;

FIG. 13 is a schematic diagram of the embodiment shown in FIG. 1,illustrating the stage when the implanting is completed;

FIG. 14 is a sectional diagram taken along the line XIV-XIV of theembodiment illustrated in FIG. 11;

FIG. 15 is a schematic diagram of the embodiment shown in FIG. 1,illustrating that the bottom is restored;

FIG. 16 is a sectional diagram taken along the line XVI-XVI of theembodiment illustrated in FIG. 15;

FIG. 17 is a partially assembled perspective view of another embodimentof the air-tight and desiccating container of the present invention;

FIG. 18 is a schematic diagram of the embodiment shown in FIG. 17,illustrating the stage of being prepared for the implanting;

FIG. 19 is a sectional diagram taken along the line XIX-XIX of theembodiment illustrated in FIG. 18;

FIG. 20 is a schematic diagram of the embodiment shown in FIG. 17,illustrating an instance during the implanting;

FIG. 21 is a sectional diagram taken along the line XXI-XXI of theembodiment illustrated in FIG. 20;

FIG. 22 is a schematic diagram showing the air-tight and desiccatingcontainer according to another embodiment of the present invention;

FIG. 23 is a schematic diagram of the embodiment shown in FIG. 17,illustrating that the bottom cover is removed and is at the stage ofbeing prepared for the implanting;

FIG. 24 is a schematic diagram of the embodiment shown in FIG. 17,illustrating the implanting operation;

FIG. 25 is a schematic diagram of the embodiment shown in FIG. 17,illustrating the stage before removing the bottom cover;

FIG. 26 is a schematic diagram of using a tear-off element to remove arelease layer when the bottom cover of the embodiment shown in FIG. 17is removed;

FIG. 27 is a schematic operation flow diagram of the air-tight anddesiccating container according to the present invention;

FIG. 28A is a schematic diagram showing the top cover not covering onthe base assembly when the needle implanting operation is completed andthe sensor is implanted into the subcutaneous portion in the firstembodiment;

FIG. 28B is a schematic diagram showing the top cover covering on thebase assembly after the needle implanting operation is completed and thesensor has been implanted into the subcutaneous portion in the firstembodiment;

FIG. 29 is a schematic diagram showing an enlarged portion of FIG. 3,illustrating that the sensor assembly is clamped inside the air-tightand desiccating container by a needle implantation support;

FIG. 30 is an assembly diagram similar to that of FIG. 1;

FIG. 31 is a schematic sectional view of the removal module according tothe present invention disposed on the surface of a living body;

FIG. 32 is a schematic sectional view taken along the x-x direction ofone of the embodiments shown in FIG. 2B;

FIG. 33 is a schematic sectional view taken along the y-y direction ofone of the embodiments shown in FIG. 2B;

FIG. 34 is a schematic sectional view taken along the x-x direction ofone of the embodiments shown in FIG. 2B;

FIG. 35 is a schematic sectional view taken along the y-y direction ofone of the embodiments shown in FIG. 2B;

FIG. 36 is a schematic sectional view taken along the x-x direction ofone of the embodiments shown in FIG. 2B;

FIG. 37 is a schematic sectional view taken along the y-y direction ofone of the embodiments shown in FIG. 2B;

FIG. 38 is a schematic sectional view taken along the x-x direction ofone of the embodiments shown in FIG. 2B;

FIG. 39 is a schematic sectional view taken along the y-y direction ofone of the embodiments shown in FIG. 2B;

FIG. 40 is a schematic sectional view taken along the x-x direction ofone of the embodiments shown in FIG. 2B;

FIG. 41 is a schematic sectional view taken along the y-y direction ofone of the embodiments shown in FIG. 2B;

FIG. 42 is a schematic cross-sectional view taken along line y-y of oneof the embodiments shown in FIG. 2B, where the housing is separated fromthe bottom cover;

FIG. 43 is a schematic cross-sectional view taken along line y-y of oneof the embodiments shown in FIG. 2B;

FIG. 44 is a schematic perspective view of the combination of the bottomcover and the housing of the present invention;

FIG. 45 is a top view of the combination of the bottom cover and thehousing according to the FIG. 44;

FIG. 46A-46D are schematic diagrams of an continuous action of openingthe bottom cover according to one embodiment of the present invention;

FIG. 47 is a schematic perspective view showing a user to remove thebottom cover from the housing by hands according one embodiment of thepresent invention;

FIG. 48 is a schematic diagram of the combination of the transmitterplaced on the base attached to a body surface via the sticker accordingone embodiment of the present invention;

FIG. 49 is an exploded schematic diagram of the transmitter, the baseand the sensor assembly of the present invention;

FIG. 50 is a schematic diagram of a housing and a bottom cover of theimplantation device according to another embodiment of the presentinvention;

FIG. 51 is a schematic cross-sectional view along the line y-y of theembodiment in FIG. 50;

FIG. 52 is a schematic diagram of a housing and a bottom cover of theimplantation device according to yet another embodiment of the presentinvention;

FIG. 53 is a schematic cross-sectional view along the line y-y of theembodiment in FIG. 52;

FIG. 54 is a schematic diagram of a housing and a bottom cover of theimplantation device according to yet another embodiment of the presentinvention;

FIG. 55 is a schematic cross-sectional view along the line y-y of theembodiment in FIG. 52;

FIG. 56 is a schematic perspective view of one embodiment of the presentinvention after the bottom cover is detached from the housing;

FIG. 57 is a schematic diagram of a housing and a bottom cover of theimplantation device according to yet another embodiment of the presentinvention and a schematic view of uncovering the bottom cover;

FIG. 58-61 are schematic diagrams of an operation flow for assembling aphysiological signal monitoring device on a surface of a living bodyaccording to an embodiment of the present invention;

FIG. 62 is another embodiment of the desiccating and air-tight storagecontainer of the present invention;

FIG. 63 is another embodiment of the desiccating and airtight storagecontainer of the present invention; and

FIG. 64 is another exemplary embodiment of the desiccating and airtightstorage container of the present invention.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT

The present invention will now be described more specifically withreference to the following embodiments. It is to be noted that thefollowing descriptions of preferred embodiments of this invention arepresented herein for the purposes of illustration and description only;they are not intended to be exhaustive or to be limited to the preciseform disclosed.

The present invention of air-tight and desiccating containerincorporates the implanting device with the sensing device, andmaintains a dry environment for the devices. Please refer to FIGS. 1-10.According to FIG. 1, the desiccating container 100 is formed therein anair-tight space due to the air-tight joint maintained by the housing 11and the bottom cover 20. The casing assembly 10 includes the housing 11,the lining piece 12 disposed inside the housing 11 and the leak-proofring 13 which is selectively added and disposed around the housing 11.The air-tight space commonly formed by the housing 11 and the bottomcover 20 is for accommodating other elements such as the implantingmodule 30, the lower mount base 50, the sensor assembly 70 and thedesiccating element 60. The lower mount base 50 and the sensor assembly70 will be separated from the desiccating container 100 after thecompletion of the implanting process and compose a form of a module tobe disposed on the skin surface of the living body that a sensor needsto be implanted thereinto. Therefore, the combination of the lower mountbase 50 and the sensor assembly 70 can be considered as a detachablemodule. It can be understood, according to the illustrations in FIGS. 3and 4, that the lower mount base 50 and the sensor assembly 70 areseparately disposed at different locations in the state of storage andto be implanted.

Referring to FIGS. 1-4, the shape of the housing 11 is like a cup, and atop wall 111 is located at the cup-bottom like portion. There is abottom opening on the lower surface 112 opposite to the top wall 111along the axis L. According to the present embodiment, a first jointportion to be jointly connected to the bottom cover 20 is defined on thebottom opening of the housing 11. The first joint portion is coupled tothe bottom cover 20 through, but not limited to, a sleeving engagement(hard interfering). The housing 11 further includes a matching portion116 having a concave shape. In one embodiment, to allow a person toobserve the desiccating condition of the desiccating element 60, adesiccation indicator 61 such as a cobalt-containing humidity indicatoror a cobalt-free humidity indicator, can be disposed at the location ofthe housing 11 or the bottom cover 20 which is made of transparent ortranslucent material. Another example for the desiccation indicator 61is a printed layer of a zeolite-containing resin, which can be judged byabsorbing moisture to make the resin layer transparent. The desiccationindicator 61 can be used by users to observe the dryness in thecontainer so as to avoid using abnormal products.

The lining piece 12 has a shape of a hollow cylindrical cup, and issleeved in the housing 11. The lining piece 12 is in close contact withthe inner surface 117 of the housing 11, and has an inner peripherysurface 121 that can define the accommodating space 14 for accommodatingthe implantation module 30, an outer peripheral surface 122 opposite tothe inner peripheral surface 121, a pair of actuating portions 123protruding from the inner peripheral surface 121, a pair of lockingportions 124 disposed along the axis L from a side of the actuatingportions 123 respectively and a plurality of slot seats 126 protrudingfrom the outer peripheral surface 122 and defining the containinggrooves 125 with the outer peripheral surface 112 respectively. Thelocking portions 124 have through holes communicating the outerperipheral surface 122 with the inner peripheral surface 121. Thecontaining groove 125 can be used to place the desiccant 60.

Since the lining piece 12 and the casing 11 are closely fitted via aplurality of mating portions 127, the relative positions of the two canbe unchanged. The gap formed between the lining piece 12 and the casing11 due to the existing of the plurality of mating portions 127 on thetop surface of the lining piece 12 can be furnished with a desiccant 60.In this embodiment, the lining piece 12 may define a desiccantaccommodating space on the top of the lining piece 12 and at least oneof a plurality of containing grooves 125 extending from the side wall ofthe lining piece 12. In another embodiment, the inner peripheral surface121 of the lining piece 12 may also include a desiccant accommodatingspace (not shown). According to another embodiment of the presentinvention, as shown in FIGS. 32 and 33, the lining piece 12 can beregarded as a part of the housing 11 or vice versa, which means that thelining piece 12 and the housing 11 can be independent components or thetwo components can be formed integrally, without departing from thescope of the present invention.

The bottom cover 20 is detachably mounted to the housing 11, and has achassis portion 21 substantially perpendicular to the axis L and aperipheral wall 22 extending from the periphery of the chassis portion21. The peripheral wall 22 has an inner side surface 221, an outer sidesurface 222 opposite to the inner side surface 221, a brim 223 connectedbetween the inner side surface 221 and the outer side surface 222, aring groove 224 recessed in the inner side surface 221 to which theconvex ring 115 can be embedded, a pair of blocking portions 226protruding from the inner side surface 221, and a slightly semicircularplate-shaped positioning piece 227 protruding from the brim 223. Thebottom opening of the housing 11 matches the configuration of the bottomcover 20. The positioning piece 227 can be nested in the matchingportion 116. The matching between the positioning piece 227 and thematching portion 116 provides a user with the function of foolproofalignment when operating to open and close the container. In addition,when the internal components of the desiccating container have adirectional requirement, the combination of the matching portion 116 andthe positioning piece 227 can be used as a set of foolproof alignment,which is beneficial to improve production efficiency. Besides, thematching portion 116 can also be used as a positioning member for thehousing 11 to be used as a reference point for estimating the amount ofdeformation of the opening of the housing 11 to make the opening of thehousing a round appearance during injection molding, which helps in theairtight process.

The outer side surface 222 of the bottom cover 20 has a force applyingportion 228 adjacent to the brim 223 and protruding from the outer sidesurface 222. The force applying portion 228 makes it easy for the userto open and remove the bottom cover 20. Furthermore, the force applyingportion 228 is provided to control the opening force to no more than 2kilogram force (kgf), so that the container can be easily opened and isresistant to negative pressure, and can be quickly disassembled by theuser with less effort.

According to this embodiment, the inner side surface 221 of the bottomcover 20 defines a second joint portion that is to be engaged, but isnot limited to other ways, with the first joint portion of the housing11. In another embodiment, the leak-proof ring 13 formed of an elasticwasher with elastic material can also be sleeved on the outer ringsurface 114 of the bottom ring portion 113. The leak-proof ring 13 isarranged on one side of the ring groove 224, and can be air-tightlysleeved on the ring portion 225 disposed on the outer side of theleakage preventing ring 13. As shown in FIG. 3, when the housing 11 andthe bottom cover 20 are assembled, the leak-proof ring 13 can make thecombination of the two at an air-tight condition. According to anotherembodiment, the ring groove 224 of the bottom cover 20 and the convexring portion 115 of the housing 11 may also form a joint in an airtightcondition. In order to provide an air-tight storage environment for thedesiccating container 100, according to another embodiment, the bottomcover 20 may also be implemented in the form of an aluminum foil (notshown), which may also provide a sealing effect.

Results from the negative pressure test for the desiccating containerstored in different temperature and humidity environments and was takenout at different times to confirm the airtight function and verify thedaily average moisture absorption of the desiccating container was donethrough the weighing test. According to the experimental results, themoisture absorption in the desiccating and airtight storage container ofthe present invention is not more than 200 mg per day, or not more than50 mg per day, or not more than 1 mg per day, or not more than 0.5 mgper day, or not more than 0.3 mg per day, or no more than 0.25 mg perday. In another embodiment, the desiccating and airtight container isallowed to reach a storage condition of relative humidity of 0 to 100%and a temperature of 0 to 45° C., or a storage condition of relativehumidity of 0 to 100% and a temperature of 0 to 40° C., or the storagecondition with relative humidity of 10 to 90% and temperature of 4 to30° C., and maintaining a storage period of at least 2 years or at least1 year, both have good air-tight effects. The present invention is notlimited by the embodiments of hard interference pattern disclosed by theexamples.

It is worth mentioning that usually a hinged connection (not shown) isdisposed between the bottom cover 20 and the housing 11 of thedesiccating container 100. By utilizing the present invention of canopening design with the convex ring and the ring groove, while operatingthe desiccating container 100 for the sensor implantation, the housing11 is more easily pressed against the surface of the biological skin forimplantation. Compared with the screw-rotating can opening design, theconvex ring and ring groove sleeving design of the present inventionmakes the manufacturing process simpler and can reduce the probabilityof production mold wearing out, which is beneficial to improve processyield.

The sensor assembly 70 includes a sensor 72 as shown in FIGS. 3-4 and31. The sensor 72 is to be implanted into the cortex P, the subcutaneousportion, of the living body to measure the living body's physiologicalsignals. The sensor assembly 70 includes a sensor base 71 and a sensor72 which connects to the sensor base 71 and is partially retained in theimplantation needle 362. The sensor base 71 has a plurality of recessedengaging portions 711 configured to be engaged with the connectingportions 383 of the auxiliary implantation seat 38. The sensor assembly70 can also be regarded as a single module. For example, the sensor 72may include a substrate 722, and at least one working electrode 724 anda reference or counter electrode 725 are disposed on the substrate 722.At least the working electrode 724 has a chemical reagent 720 includingat least one analyte-responsive enzyme 726 and polymer membrane layer728. The chemical reagent 720 is configured to obtain data on certainphysiological parameters in the living body, such as glucoseconcentration or other parameters in interstitial fluid.

The sensor 72 is not limited to other types of electrode arrangementstructures. The sensor 72 must be kept airtight and dry while storageand before implantation, so the accommodating space 14 of the airtightdesiccating container 100 for carrying the sensor assembly 70 isprovided with the desiccant 60 to maintain the long-term stabilityperiod of the reagent, such as one or more years. The gaps between theelements in the desiccating container 100 of the present invention canbe used as venting holes for the desiccant 60, and communicate with thesensor 72, so that the desiccant 60 maintains a good function formoisture absorption. Notably, in another embodiment, the air-tightcontainer 100 of the present invention does not even need to place adesiccant 60. Under a state of excellent air-tightness, the containerinterior can have a very low humidity as at the initial productionstage, which keeps the sensor away from being affected by humidity andmaintains the long-term efficacy of the chemical reagent. Thus, thesensor 72 can have a consistently good accurate performance for one yearor two years or even longer, during the storage period.

The desiccant 60 may be disposed at any appropriate position inside thedesiccating container 100. As shown in the embodiment illustrated inFIG. 1 or 2A, the desiccant 60 is disposed in the containing groove 125of the lining piece 12, and the implanting module 30 carrying the sensorassembly 70 is located in the accommodating space 14 inside the liningpiece 12. From another perspective, the liner 12 is disposed between thehousing 11 and the implanting module 30. Desiccant 60 can also be placedbetween the plurality of mating portions 127 on the outer peripheralsurface 122 of the liner 12. According to another embodiment, as shownin FIGS. 2A and 3-4, the desiccant 60 may be sandwiched between theouter peripheral surface 122 of the lining piece 12 and the housing 11,or disposed on the inner peripheral surface 121. The desiccant 60 mayalso be disposed at an appropriate position of the implanting module 30or the bottom cover 20, or the desiccant 60 may be disposed near thesensor assembly 70, or the desiccant 60 may be integrally formed withthe sensor base 71. The desiccant 60 can be combined and arranged atdifferent positions according to environmental requirements. Thedesiccant 60 can be a desiccant-incorporated polymer, a water-absorbingmaterial, a hygroscopic material, a molecular sieve drying sheet, adesiccant-incorporating plastic sheet, or a dry sheet formed byinjection molding with internal components of the container 100.

The implanting module 30 is installed in the accommodating space 14, andincludes a main body 31 having a hollow cylindrical shape, an main cover32 connected to the main body 31 and defining a displacement space 301together with the main body 31, a needle implanting seat 33 movablydisposed in the displacement space 301 along the axis L, a first elasticelement 34 disposed between the needle implanting seat 33 and the maincover 32 in a pre-compressed manner, a needle extracting seat 35slidably installed inside the needle implanting seat 33 along the axisL, a needle implanting piece 36 connected to the needle extracting seat35, and a second elastic element 37 disposed between the needleimplanting seat 33 and the needle extracting seat 35 in anotherpre-compressed manner. The first elastic element 34 is configured toprovide the needle implanting seat 33 with elastic force to move awayfrom the main cover 32 along the implanting direction F. The secondelastic element 34 is configured to provide the needle extracting seat35 with elastic force to move along the needle extracting direction R.The components in the implanting module form a driving group to drivethe needle implanting piece 36 causing the implanting module 30 torelease a force to implant the sensor 72 underneath the skin of a livingbody.

The main body 31 has a bottom wall 311, a cylinder wall 312 intersectingand connected to the bottom wall 311, a hollow tubular duct 313protruding from the bottom wall 311, two elastic pieces 314 connected tothe cylinder wall 312 and opposite to each other, and a pair of latchingportions 315 which can be engaged with the locking portions 124respectively. The cylinder wall 312 has a pair of slide grooves 310extending along the axis L, a pair of recessed portions 316, and a pairof stopping portions 317 adjacent to the recessed portions 316, and apair of buckle ears 318. The duct 313 has a push-out hole 319 which isnarrower inward and wider outward. The slide grooves 310 is connected tothe pushing holes 319, and the elastic pieces 314 have elasticity thatmay cause bias relative to the axis L. The latching portions 315 arerespectively disposed on the movable ends of the elastic pieces 314.

The main cover 32 has a central hole 321 corresponding to the axis L, apair of buckle holes 322, which can be buckled on the buckle ears 318respectively, and a pair of constraint elements 323 disposed along theaxis L and opposite to each other.

The needle implanting seat 33 has a flat plate portion 331, an innercylindrical member 332 intersecting and connected to the flat plateportion 331, an outer cylindrical member 333 intersecting and connectingto the flat plate portion 331 and surrounding the inner cylindricalmember 332, a limiting element 334 disposed on the inner tube member 332for keeping the needle extracting seat 35 at a constant locationrelative to the needle implanting seat 33, a pair of buckle portions 335respectively disposed on the outer cylindrical member 333 and detachablysitting on the stopping portions 317, and a pair of limiting grooves 336extending parallel to the parallel axis L and adjacent to the limitingelement 334. The buckle portions 335 are in the shape of springs andhave elasticity that may cause bias relative to the axis L.

According to one embodiment of the present invention, the first and thesecond elastic elements 34, 37 are compressing springs.

According to one embodiment of the present invention, the needleimplanting piece 36 has a main body portion 361 and a needle 362 havinga hollow shape and connected to the main body portion 361.

Notably, the implanting module 30 further includes a auxiliaryimplantation seat 38 detachably disposed on the needle-implanting piece36, and the sensor assembly 70 detachably maintains a position relativeto the auxiliary implantation seat 38. The auxiliary implantation seat38 has a base mount 381, three fins 382 extending outward from the basemount 381 and a plurality of connecting portions 383 protruding from thebottom of the base 381 and having a tenon shape. The fins 382 each havea plurality of recesses 384, and are allowed to be compressed in aradial direction perpendicular to the axis L and have the ability tospring outward after being compressed. Due to the constraint positionformed by the auxiliary implantation seat 38 and the main body 31 beforethe needle is implanted, the left-right deflection and pulling can beavoided when the needle is implanted underneath the skin of thebiological body. It improves the stability of the needling and reducesthe feeling of pain on the biological body or the patient. The sensorassembly 70 can be detachably carried on the auxiliary implantation seat38. In other embodiments, the auxiliary implantation seat 38 may also beintegrated with other components in the implant module 30 or in sensorassembly 70 (not shown).

The fixing members 40 are respectively installed in the slide grooves310 of the main body 31, can slide along the slide grooves 310, and eachof which has a pushing portion 41 corresponding to the blocking portions226, a supporting portion 42 opposite to the pushing portion 41, a firsthook 43 disposed between the pushing portion 41 and the supportingportion 42, and a guiding portion 44 disposed between the pushingportion 41 and the supporting portion 42 and the guiding portion 44having a guide slanting surface 441.

The lower mount base 50 is detachably positioned relative to the mainbody 31. The sensor component positioning portion on the lower mountbase 50 includes a groove 78 configured to allow the sensor assembly 70to be buckled and positioned after detaching from the auxiliaryimplantation seat 38. The lower mount base 50 has a base mount 51, anadhesive pad 52 fixed to the base mount 51, a group of buckles 53disposed on the base mount 51, a second hook 54 configured fordetachably hooked with the first hooks 43, and a release layer 55releasably attached to the adhesive pad 52 and can be removed prior tothe manufacturing process.

The base mount 51 has a sensor assembly positioning portion 511 forpositioning the sensor assembly 70. The sensor assembly positioningportion 511 can be an elastic sheet material with a closed top surface512 to prevent contamination to the sensor assembly 70. The buckles 53protrude from the top surface 512 and have an inverted V-shaped crosssection, and are elastic at least in one direction.

In another embodiment (referring to FIGS. 38-39), the buckles 53 can bereplaced with a double-sided sticker 56, the bottom of the sensor base71 is bonded to the double-sided sticker 56, and the sidewall of thesensor base 71 is sandwiched by the sensor assembly positioning portion511. In another embodiment (referring to FIGS. 40-41), the sensorassembly positioning portion 511's elastic ring 514 and the sensor base71 can be press-fitted to cause the sensor assembly 70 to be positionedon the lower mount base 50, and the group of buckles 53 are no longernecessary. In another embodiment, the lower mount base 50 and the sensorassembly 70 may be pre-assembled (not shown).

In order to further describe the effects of the cooperation of theelements of the present invention, the use of technical means, and theexpected effects, it will be explained as follows, which is believedthat the skilled persons in the art can have a deeper and specificunderstanding of the present invention.

In the embodiment shown in FIGS. 3 and 4, when the first embodiment ofthe desiccating and airtight container 100 of the present invention isassembled, the bottom cover 20 is air-tightly closed to the housing 11,in an unused state, the ring groove 224 embedded by the convex ring 115can be used to air-tightly combine the bottom cover 20 and the housing11, an air-tight space is formed inside the casing assembly 10 (or thehousing 11) and the bottom cover 20, and in combination with thedesiccant 60, the purpose of moisture resistance can be achieved so asto ensure the detection accuracy of the sensor 72. In anotherembodiment, the convex ring 115 may be disposed on the bottom cover 20,and the ring groove 224 is provided on the housing 11.

In the storage state, the position of the needle implanting seat 33 inthe displacement space 301 is adjacent to the main cover 32, and thestopping portions 317 of the main body 31 and the buckle portions 335 ofthe needle implanting seat 33 form a state of constraint. The needleimplanting seat 33 is located in an upper position. The first elasticelement 34 is pre-compressed between the needle implanting seat 33 andthe main cover 32, and contains a releasable elastic force. Theconstraint elements 323 are respectively inserted in the limitinggrooves 336, and are configured to restrict the limiting element 334from radial deflection. The limiting element 334 is used to generate alatch on the needle extracting seat 35 positioned relative to the needleimplanting seat 33, so that the displacement of the needle implantingseat 33 in the implantation direction F is restricted. There is adistance D between the main cover 32 and the lining piece 12.

When the desiccating container 100 is completely assembled and not yetused, the fixing members 40 abut against the bottom cover 20. Morespecifically, the pushing portions 41 of the fixing members 40 arerespectively constrained by the blocking portions 226 of the bottomcover 20. The method of setting of the fixing members 40 can generate amovement restriction for the lining piece 12 to prevent the dryingcontainer 100 from false triggering due to accidentally falling andcausing the internal components to scatter or malfunction, to ensure thepurpose of effective use. Meanwhile, the supporting portions 42 of thefixing members 40 are also used to generate a supporting effect on thesensor base 71 of the sensor assembly 70, and the first hooks 43 areengaged in the second hooks 54, so that the lower mount base 50 ispositioned relative to the main body 31.

As shown in FIGS. 5-6, when the bottom cover 20 is removed or opened,and the desiccating container 100 is arranged on the skin surface of thebiological body (shown by the dashed line in the horizontal direction),also referring to FIGS. 7-8, the housing 11 can be operated to move thelining piece 12 downward, that is, in the direction toward the skinsurface. During the process, the actuating portions 123 of the liningpiece 12 push the buckle portion 335 along its inclined surface tofinally release the state of constraint between the stopping portion 317and the buckle portions 335 and cause the first elastic element 34 inthe implanting module 30 to automatically release a force to push theneedle implanting seat 33 in the implantation direction F so as toimplant the sensor 72 into subcutaneous of the living body. When thehousing 11 is pressed downward by an external force, the bottom edge ofthe lining piece 12 will drive the guiding portion 44 of the fixingmembers 40, and the fixing members 40 will simultaneously move away fromthe axis L and render the support portions 42 away from the support ofthe sensor base 71, so that the first hooks 43 are also separated fromthe second hooks 54 respectively. The use of the guide slanting surfaces441 can make the movement of the lining piece 12 driving the fixingmembers 40 quite smooth.

During the implantation process, when the housing 11 is operated todrive the lining piece 12 downward, the distance D between the maincover 32 and the lining piece 12 disappears, and only the actuatingportions 123 on the inner peripheral surface 122 of the lining piece 12slide along the slope of the buckle portion 335, and the external forceapplied to the housing 11 is not transmitted to the main body 31 downbelow, so the implanted living body does not feel the external force.And the restoring force of first elastic member (34) is configured notto act cover body (12) during the depression of said cover body (12).After the lining piece 12 being pressed by the user, the actuatingportions 123 will be stuck underneath the main body 31, and thus thelining piece 12 cannot be moved upward while the user does not feel anyvibration nor noise. As shown in FIGS. 7-8, at this moment, theconstraint member 323 of the main cover 32 and the limiting groove 336of the needle implanting seat 33 are still in a constraint state, andthe needle-extracting constraint structure has not been released. Asshown in FIGS. 8-10, after the bottom cover 20 is removed or opened andduring the implantation process, the lower mount base 50 is separatedfrom the sensor assembly 70, and when the detachable module is implanteddue to the force released by the implanting module 30, the sensorassembly 70 is assembled to the lower mount base 50 and the sensor 72 isimplanted under the skin of the living body.

In the embodiments shown in FIGS. 3-10, the main cover 32 in theimplanting module 30 is an individual component. Those skilled in theart can combine the devices according to the drawings. For example,according to different embodiments, as shown in FIGS. 36-37, theoperation processes of the automatic needle implantation and automaticneedle extraction are similar to those of the previous embodiment, andthe lining piece 12 can be designed to have the function of the maincover 32, therefore the main cover 32 doesn't need to be held as anindividual component, and the main body member 31 and the lining piece12 are connected to each other. The implanting module 30 includes a mainbody member 31 connected to the lining piece 12, and the main bodymember 31 and the lining piece 12 constitutes a displacement space 301.

The main body 31 has a pair of latching portions 315 which can beengaged with each of the locking portions 124 respectively, a needleimplanting seat 33 that can detachably form a constraint relative to thelining piece 12 and movable in the displacement space 301 between themain body 31 and the lining piece 12, a first elastic element 34 whichis a pre-compressed spring disposed against the needle implanting seat33 and the lining piece 12 therebetween, a needle extracting seat 35which is capable of maintaining a constraint relative to the needleimplanting seat 33 and a second elastic element 37 which ispre-compressed between the needle implanting seat 33 and the needleextracting seat 35. The inner peripheral surface of the lining piece 12has at least one actuating portion 123, and the needle implanting seat33 has a buckle portion 335 which can be driven by the actuating portion123 and is detachably disposed in the main body 31. By way of the buckleportion 335 of the needle implanting seat 33 resisting the stoppingportion 317 of the main body 31, a triggering constraint structure isformed between the needle extracting seat 33 and the main body 31.

In another embodiment, as shown in FIGS. 34-35, even the separate liningpiece 12 and the main cover 32 may not be needed, since the housing 11has the technical features including the lining piece 12 and the maincover 32. The implanting module includes: a main body 31 coupled to thehousing 11 and forming a displacement space 301 with the housing 11, aneedle implanting seat 33 that can detachably form a constraint relativeto the housing 11 and movable in the displacement space 301 between themain body 31 and the housing 11, a first elastic element 34 which is apre-compressed spring disposed against the needle implanting seat 33 andthe housing 11 therebetween, a needle extracting seat 35 which iscapable of maintaining a constraint relative to the needle implantingseat 33 and a second elastic element 37 which is pre-compressed betweenthe needle implanting seat 33 and the needle extracting seat 35.

In another embodiment, as shown in FIGS. 32-33, the housing 11 and thelining piece 12 are integrally formed to constitute a casing assembly10. The implanting module includes 31: a main body 31 coupled to thecasing assembly 10 and forming a displacement space 301 with the casingassembly 10, a needle implanting seat 33 that can detachably form aconstraint relative to the casing assembly 10 and movable in thedisplacement space 301 between the main body 31 and the casing assembly10, a first elastic element 34 which is a pre-compressed spring disposedagainst the needle implanting seat 33 and the casing assembly 10therebetween, a needle extracting seat 35 which is capable ofmaintaining a constraint relative to the needle implanting seat 33 and asecond elastic element 37 which is pre-compressed between the needleimplanting seat 33 and the needle extracting seat 35.

Referring to FIGS. 9-10, when the first elastic element 34 in theimplanting module 30 releases the force, the needle implanting seat 33is pushed away from the main cover 32, and the constraint of theconstraint elements 323 of the main cover 32 in the limiting groove 336of the needle implanting seat 33 is automatically released. At thismoment, while the housing 11 is pressed down, the needle extracting seat35 maintains at a position relative to the needle implanting seat 33 dueto the limiting element 334.

Referring to FIGS. 11-12, because of the detachment of the constraintelement 323, the limiting element 334 that initially held the needleextracting seat 35 at the position relative to the needle implantingseat 33 can no longer keep itself in the initially position and deviatesin the direction of the limiting groove 336, so that the needleextracting seat 35 is released from the restriction of the needleimplanting seat 33 and the constraint on the movement of the needleextracting seat 35 in the withdrawal direction R is released. Therefore,the second elastic element 37 spring-loaded between the needleimplanting seat 33 and the needle extracting seat 35 may release itselastic force and make the needle extracting seat 35 moving in theneedle extraction direction R at this moment, so that the needle 362which has just completed the implantation procedure can be withdrawnimmediately to complete continuous implanting and extracting operation.

The first and second elastic elements 34, 37 can be made of helicalsprings or pneumatic/pneumatic elements for examples. Because the needleimplantation and needle extraction are completed through theinstantaneous elasticity release of the two pre-compressed elasticelements 34, 37, the present invention of implanting a sensor from animplantation device stored in container into a subcutaneous by using anautomatic mechanism can complete the needle implantation and needleextraction operation in a very short time, which does not make theimplanted person feel uncomfortable, even the living body have yet apainful feeling when finishing the implantation process. The user doesnot feel the reaction force of the first elastic element 34 whenpressing the housing 11, thus the smoothness of the automatic needleimplantation and withdrawal process is improved, and the time forcompleting the automatic needle implantation and the automatic needlewithdrawal operation is no more than 100 milliseconds (ms), or no morethan 50 ins, or no more than 8 ms, 6 ms, 4 ms or even 2 ms.

In addition, according to the present invention, after the externalforce is applied to the top wall 111 of the housing 11, the actions suchas unlocking, implanting the needle and extracting the needle can becontinuously completed. During the operation, the user can complete theimplantation without releasing hand from the housing 11, the implantingdevice is functioned by means of elastic needle implantation, ratherthan relying on the user's hand to press it down. Therefore, theimplantation device of the present invention can effectively solve theproblem that the conventional method will affect the smoothness of theimplantation and needle extraction due to the user's operation poorproficiency. FIGS. 13-14 show that the needle 362 is completelywithdrawn back into the accommodating space 14 of the lining piece 12after the needle extraction process, and more clearly inside theauxiliary implantation seat 38 to prevent the sharp needle 362 frombeing exposed outside the bottom opening to cause an accident.

FIGS. 15-16 shows how the bottom cover 20 is re-coupled after use. Afterthe implantation is completed, the user can easily combine the bottomcover 20 and the housing 11 with the aid of the positioning piece 227 onthe bottom cover 20 and the matching portion 116 at the bottom openingof the housing 11 to achieve the purpose of accurate alignment andfoolproof. In addition, the desiccating and airtight storage device 100can be used as a waste storage means. The used lower base mount 50 canbe detached and stored in the original desiccating and airtight storagedevice 100, allowing the user to discard in accordance with medicalwaste disposal requirement.

As shown in FIGS. 17-19, another embodiment of the desiccating andairtight container according to the present invention is different fromthe first embodiment in that a protective ring 80 is added thereon, andthe protective ring 80 is sleeved on the bottom of the casing 11. Thelower base mount 50 is disposed on the inner side of the bottom edge ofthe protective ring 80 before the implantation operation, so when thebottom edge of the protective ring 80 abuts against the skin surface ofthe living body, the lower base mount 50 will not contact the skinsurface. The user can move the implantation device to the position to beimplanted, then the triggering action of pressing down the casingassembly 10 (or the housing 11) is performed (as shown in FIGS. 20 and21), and the housing is pressed down. After the implantation, theprotective ring 80 can be retracted relative to the casing assembly 10(or the housing 11) by applying a force, and the lower base mount 50 isthen adhered to the skin surface. Therefore, with the aid of theprotective ring 80 of this embodiment, it can be adjusted to therequired skin position before the needle implantation operation isperformed, which is quite convenient in use.

Referring to FIGS. 22-26 (for the convenience of explanation, FIGS.22-26 are only shown in simplified draws), the desiccating container 100of the present invention, which integrates with the implantation deviceand the sensor, has a housing 11 and a bottom cover 20 jointly form anair-tight combination structure with an air-tight condition inside, andthe desiccant 60 can be disposed at any appropriate position inside thedesiccating container. In addition, in an embodiment, the desiccant isdisposed on the inner peripheral surface of the housing 11 or the outerperipheral surface of the lining piece 12. At least one componentrelated to the peripheral surfaces or the implanting module 30 isintegrally formed with the desiccant 60, or configured with a containingspace for he desiccant 60 to be placed (as shown in FIGS. 22 and 23), orthe sensor assembly 70 has a desiccant 60 (not shown), or as shown inFIG. 25, a desiccant layer 62 is formed on the inner peripheral surfaceof the housing 11 or the bottom cover 20 or an accommodating space isarranged for the desiccant 60 to be placed (not shown), which keeps theinside of the desiccating container dry and prevent the sensor assembly70 from getting wet, especially to prevent the chemical reagent 20 onthe sensor 72 from deliquesced (as shown in FIG. 31) to ensure thedetection accuracy of the sensor 72. The chemical reagent 720 comprises,for example, at least one analyte-responsive enzyme 726 and a polymerfilm layer 728.

In another embodiment, as shown in FIGS. 25 and 26, the lower base mount50 further has a tearing element 23 attached to the chassis portion 21.The tearing element 23 is connected to a release layer 55 which is onthe adhesive pad 52. When the container is opened (that is, the bottomcover 20 is removed), the release layer 55 can be torn away along withthe tearing element 23, so that the user can tear off the release layer55 and expose the adhesive pad 52 right before the implantation, whichhelps to improve adhesion of the adhesive pad 52 to the skin.

In another embodiment, the sensor 72 may be designed to have a certainrigidity, so it is not necessary to be equipped with the needle implantmember 36, and the implant module 30 does not need to include the needleextraction device.

In addition, referring to FIG. 27, the operating method of theimplantation device according to the present invention can be describedas follows:

As shown in FIGS. 3 and 4, the housing 11 is combined with the bottomcover 20 to form the accommodating space 14 therein. The implantingmodule 30 is disposed inside the accommodating space 14. The needleimplanting seat 33 and the main body forms a triggering constraintstate. The bottom cover 20 constrains the fixing members 40 to prevent achange from the first operating status (the storage, not implantingstatus) to the second operating status (the implanting status) underunexpected conditions such as accidental falling and dropping down tothe ground.

As shown in FIGS. 5 and 6, the user can remove the bottom cover 20 fromthe bottom of the housing 11 to release the constraint to the fixingmembers 40, and place the lower base mount 50 on the skin surface of theliving body. In some embodiments, the bottom cover 20 is not removed butopened from the housing during the implantation process.

As shown in FIGS. 7-12, the user can press the housing 11 to release thetriggering constraint and cause the implanting module 30 to enter thesecond operating status from the first operating status. When theimplanting module 30 enters the second operating status, the sensorassembly 70 is positioned on the lower base mount 50 and the needle (orsharp) 362 is implanted to the subcutaneous portion, completing theneedle implantation process. As shown in FIGS. 13 and 14, during theneedle extraction process, the implanting module 30 moves toward thelocation at the first operating status, and thus the needle 362 iswithdrawn back inside the housing 11 without exposing to the outside.

As shown in FIGS. 15 and 16, the bottom cover 20 is re-coupled back tojoin the housing 11.

Notably, in the assembly sequence of the components of the presentinvention, the first elastic element 34, the needle extracting seat 35,the second elastic element 37, and the needle implanting seat 33 arepreviously installed between the main cover 32 and the main body 31, theneedle implanting piece 36 is finally put on the auxiliary implantationseat 38 and the sensor assembly 70 therebetween. The needle implantingpiece 36 is used to couple to the needle extracting seat 35, whereby thesensor assembly 70 and the implant module 30 forming a clutch design,which can not only greatly improve the assembly yield, but alsoeffectively reduce the cost of the sensor assembly 70.

The assembly method of the desiccating container 100 of the presentinvention is shown in FIGS. 1 and 28A/B-29. After the components in theimplantation module 30 are assembled, the housing 1 is set on theimplantation module 30. At this time, the sensor assembly 70 has beenpre-clamped inside the implanting module 30 through the auxiliaryimplantation seat 38, and finally the bottom cover 20 is combined withthe housing 11. In other words, the present invention does not requirethe operation of grasping the sensor assembly 70 onto the lower basemount 50 by the implanting module 30. Basically, the above-mentionedassembly method of the desiccating container 100 is assembled at thefactory end, but it is not limited to be assembled by a medical staff ora user by splitting and implanting the module 30. When the user wants touse the apparatus, he or she only needs to easily operate theimplantation device, such as pressing the drying container. The sensorassembly 70 on the base 50 is setting through the implantation process,and the adhesive pad 52 of the base 50 will stick the lower base mount50 to the skin surface.

FIGS. 28A and 28B show that after the sensor 72 is implanted under theskin surface P of the living body, the sensor assembly 70 and the base50 that are simultaneously disposed on the skin surface P of the livingbody need to be equipped with the transmitter 90 to work. Thetransmitter 90 is used to process the physiological signals measured bythe sensor 72 and allow the signals to be transmitted to the outside.FIG. 28A shows that the transmitter 90 is not installed on the lowerbase mount 50, and the outline of the upper dotted line in FIG. 28Bshows the transmitter 90 which is installed on the lower base mount 50in the form of an upper cover. The signals detected by the sensing end721 is forwarded to the transmitter 90 via the signal output end 723,and then transmitted outward by the transmitter 90. In order to reducethe number of components to be implanted during the implantation processand also reduce the loading of the desiccating container, the detachablemodule of the present invention does not include a transmitter. Theseparately arranged the transmitter 90 and the sensor assembly 70 are toensure the electronic parts are not damaged by the sterilizationprocess, so the production yield of the device can be improved.

Please refer to FIGS. 42 and 43, both are regarded as a schematiccross-sectional view along the line y-y of one of the embodiments shownin FIG. 2B, but the housing 11 and the bottom cover 20 in FIG. 42 areseparated. A convex ring 115 beside the bottom opening 111′ under thehousing 11, which is used to combine with the ring groove 224 of thebottom cover 20, so that the bottom cover 20 and the housing 11 can beengaged tightly through hard interference. In FIG. 42, a bottom coverconvex ring 224′ is formed near the bottom cover opening 20′ to abut theconvex ring 115, and a housing ring groove 115′ is formed on the housing11 to accommodate the bottom cover convex ring 224′. It can be seenthat, in FIG. 43, the bottom cover convex ring 224′ is located above theconvex ring 115, and the convex ring 115 is also located in the ringgroove 224, thus achieving the effect of hard interference andpreventing the bottom cover 20 from being separated from the bottomopening 111′. The convex ring 115 and the housing ring groove 115′illustrated in FIGS. 42 and 43 face outward, i.e. opposite to the bottomopening 111′, while the ring groove 224 and the bottom cover convex ring224′ face inward, i.e. facing the bottom cover opening 20′. Therefore,if the bottom cover 20 is to be removed from the bottom opening 111′,the bottom cover convex ring 224′ must pass through the convex ring 115,that is, break through the barrier of the convex ring 115. In addition,a leak-proof ring 13 (referring to FIG. 4) can be additionally providedon the housing ring groove 115′, which is not only tightly sealed withthe housing ring groove 115′, but also tightly sealed with the bottomcover convex ring 224′ so as to achieve an airtight and moisture-proofeffect. In a different embodiment, the convex ring 115 is disposed onthe bottom cover 20 while the ring groove 224 is on the bottom opening111′.

Please refer to FIGS. 44 and 45, it can be seen that the lateral surfaceof the housing 11 has a recessed portion 118 and a flange 118′, thebottom cover 20 has a operating portion 228, and the opposite endnaturally becomes a force support portion 228′ providing support in theprocess when the bottom cover 20 is opened. The principle of forceapplication is that a distance D′ from the force support portion 228′ tothe operating portion 228 and the applied force (F′) form a forcemoment, that is, the “force moment” is equal to the “distance (D′)”multiplied by the “applied force (F′)”. Therefore, the size of thehousing 11 and the magnitude of the force required for opening thehousing 11 can be adjusted by controlling the distance (D′) and theapplied force (F′).

For example, if the implant device is to have better air-tightness, inprinciple, the tighter the bottom cover 20 and the housing 11 are, thebetter, but this also results in excessive force required to open thebottom cover 20, which is extremely inconvenient to use. When the userapplies excessive force in order to open the bottom cover 20, theimplant device is often thrown out of the hand, causing damage to theinternal object. Taking the implantation device of the present inventionas an example, the inventor devised a cover-opening moment design of theimplantation device that can take both easy opening and air-tightness ofthe device into account. Considering that the container may accommodatedifferent forms or different sizes of needle implanting mechanismsand/or needle subtracting mechanism, 15˜100 mm is a very appropriatedistance, and the preferred range is 30˜80 mm for the distance D′ fromthe operating portion 228 to the force support portion 228′. Regardingthe applied force F′, a larger range is 0.2˜10 kgf, a common range is0.5˜6 kgf. If one wants to open the bottom cover 20 with a smallerforce, the range falls within 1˜3 kgf, or the opening force can be lessthan or equal to 2 kgf.

Therefore, through the arrangement and combination of the range ofapplied force F′ and that of the distance from the support part to theforce D′, the “applied moment” is approximately 3 to 1000 kgf-mm, abetter range is 6 to 800 kgf-mm, an even better range is 15 to 480kgf-mm, and the much better range is 30 to 240 kgf-mm. If one needs toopen the container with smaller force, the moment can be less than orequal to about 200 kgf-mm. When the size of the bottom opening isunchanged, the applied moment can be adjusted by adjusting the size ofthe operating portion 228. Because the operating portion 228 is a convexportion, the length (L′) of the convex portion is no less than 1millimeter.

As shown in FIGS. 46A to 46D, which is a schematic diagram of thecontinuous action of opening the bottom cover 20 according to anembodiment of the present invention, when the operation portion 228 isoperated, a side opening op between the housing 11 and the bottom cover20 can be formed due to the applied moment to make the bottom cover 20leave the bottom opening 111′ of the housing 11, so that the housing 11is in an operable state, and the implantation module 30 canautomatically release a force to implant a part of the sensor 72subcutaneously to measure the physiological signal. In addition, thebottom cover 20 has a positioning piece 227 for matching with thematching portion 116 on the housing 11 (referring to FIG. 1 and FIG.2B). The bottom cover 20 has a center point 20C. A first imaginary lineL1 extends from the center point 20C to the matching portion 116 (thepositioning piece 227), and the center point 20C extends a secondimaginary line L2 toward the operating portion 228. The first and secondimaginary lines (L1, L2) form an angle 20A between 5 and 180 degrees.

Please refer again to FIGS. 46A to 46D, which are schematic diagrams ofthe continuous action of opening the bottom cover 20 of anotherembodiment of the present invention. The series of continuous actiondiagrams are based on the side view of the housing 11 of the presentinvention combined with the bottom cover 20 facing upward. First, pleaselook at FIG. 46A, which shows that the bottom cover 20 has an operatingportion 228, and the opposite end of the operating portion 228 forms aforce support portion 228′. When a user tends to open the bottom cover20, he/she may apply the applied force F′ in the direction away from thehousing 11 at the operating portion 228. In one embodiment of thepresent invention, the bottom cover 20 is formed of a relatively elasticmaterial. Because there is a desiccant 60 in the housing 11, when itabsorbs moisture, the air pressure inside the housing 11 is slightlyreduced to be less than the atmospheric pressure, so the atmosphericpressure provides additional pressure to make the bottom cover 20 fitmore closely to the housing 11.

In FIG. 46A, when the operating portion 228 is pushed by the appliedforce F′ but the side opening (or partial side opening) OP is not yetformed between the bottom cover 20 and the housing 11, the firstabutment R-A is located near the root portion 228 r and the outwardlyprotruding operating portion 228 can provide an additional force arm forthe applied force F′ to increase the moment for opening the bottom cover20. Once a slight amount of detachment is generated between the bottomcover 20 and the housing 11, the inflow of external air can balance theinternal and external air pressure of the housing 11, so it is easier todetach the bottom cover 20 from the housing 11.

Referring to FIGS. 46B to 46D, as the applied force F′ continues to beapplied to the operating portion 228, the side opening OP graduallyexpands, and the position where the resistance force generated due tothe combination between the bottom cover 20 and the housing 11 is movedfrom the first abutment R-A to the second abutment R-B, or, according toa different perspective, from the vicinity of the root portion 228 r ofthe operating portion 228 to the force support portion 228′. As shown inFIG. 46B, the second abutment R-B is farther from the operating portion228, so the force arm is longer and the moment is greater, and thus theopening operation is easier. Similarly, in FIG. 46C, the distancebetween the third abutting location R-C and the operating portion 228 isfarther than that of the second abutting location R-B and the operatingportion 228, so the force arm is longer and the opening application ismuch easier. Finally, in the situation of FIG. 46D, the bottom cover 20is about to be fully opened. At this moment, the fourth abutment R-Dalmost coincides with the force support portion 228′, and the length ofthe entire force arm is close to the diameter of the bottom cover 20plus the length of the operating portion 228. Although the deformationof the bottom cover 20 in FIGS. 46A to 46D is a bit exaggerated, as amatter of fact, if the bottom cover 20 is made of a stiffer material,the deformation will be quite small when the bottom cover 20 is opened.Nonetheless, the change at the force support portion 228′ is stillsimilar as that shown in FIGS. 46A to 46D.

Please refer to FIG. 47, disclosing that the user holds the housing 11with one hand, and apply the force F′ to pulls the operating portion 228with the fingers of the other hand to open the bottom cover 20, and aside opening OP between the bottom cover 20 and the housing 11 isformed. The manner for holding the housing 11 can be chosen according touser's convenience. Since the direction of force borne by the forceapplying portion 228 is away from the bottom opening 111′, the clampingbetween the convex ring 115 and the ring groove 22 during the bottomcover 20 opening process will also cause the applied force F′ to givethe housing 11 a tendency to move in the direction of the applied forceF′. However, the user must be able to hold the housing 11 to resist thistendency so as not to allow the housing 11 to accidentally fly out. Therecess 118 of the housing 11 of the present invention (referring to FIG.29) is configured for the user's hand to hold firmly, and because theflange 118′ stops the hand, the housing 11 is not easy to come out ofthe hand along the axial direction of the housing 11.

Please refer to FIGS. 48 and 49, where it can be seen that the sensor 90is disposed on the lower mount base 50, and the second positioningportion 90′ of the sensor 90 fits with the first positioning portion 51′of the lower mount base 50, which also has a foolproof effect, that is,if the mounting direction of the sensor 90 is opposite to that in FIG.48, it cannot be disposed on the lower mount base 50. The sensorassembly 70 is disposed on the sensor assembly positioning portion 511during the implantation process. Refer to FIG. 28B. The signal sensingend 721 of the sensor 72 is implanted subcutaneously, and the other endof the sensor 72 is the signal output end 723 exposed at the top of thesensor base 71. When the transmitter 90 is covered on the base 50, thesignal output end 723 will be electrically connected to the electricalconnection port 921 in the input portion 92 of the transmitter 90, andthen the transmitter 90 will wirelessly transmit the physiologicalsignal measured by the sensor 72. The transmitter 90 is fixed on thelower mount base 50 through the coupling of its own sensor fixing groove91 and the sensor fixing buckle 57 on the lower mount base 50. Anadhesive pad 52 (see FIG. 48) is provided at the bottom of the base 50,and the sensor module (or detachable module, including the base 50 andthe sensor assembly 70) is fixed on the surface P of the biological skinthrough the adhesive pad 52.

Please refer to FIGS. 50 and 51, showing that a second operating portion228 a is a recessed structure extending along the outer side wall of thebottom cover 20, and the recessed structure can provide with the fingersgreater friction to facilitate the user to detach the bottom cover 20from the bottom opening 111′ in a similar manner. As to the connectionrelationship among elements such as the convex ring 115, the housingring groove 115′, the ring groove 224, and etc. is the same as theillustration in FIG. 42, there is no need to repeated here.

Please refer to FIGS. 52 and 53, showing that a third operating portion228 b is a concave structure which can provide the fingers with arelatively larger friction force to facilitate the user to detach thebottom cover 20 from the bottom opening 111′ in a similar manner.Different from the embodiments in FIGS. 51 and 42, the convex ring 115and the housing ring groove 115′ on the housing 11 face inward, that is,point to the center of the bottom opening 111′, while the ring groove224 and convex ring 224′ of the bottom cover 20 face outward, that is,facing the convex ring 115 and the housing ring groove 115′. It can beappreciated that, in the embodiment of FIG. 53, the ring groove 224 andthe bottom cover convex ring 224′ are surrounded by the convex ring 115and the housing ring groove 115′. Therefore, when the user squeezes thethird operating portion 228 b, the bottom cover 20 will be slightlyconcaved inward, so that the ring groove 224 and the convex ring 115 areseparated from the contact state, and a gap is created for air to flowin, so that the housing 11 can no longer maintain negative pressure,that is, the air pressure inside and outside the housing 11 is balanced,making it easier for the user to detach the bottom cover 20.

Please refer to FIGS. 54 and 55, which disclose that the bottom coverouter wall 228 c of the bottom cover 20 can directly serve as anoperation portion, that is, the user may directly apply a force on thebottom cover outer wall 228 c and a force to the bottom cover 20 alongthe direction away from the housing 11 in order to open the bottom cover20. Since the entire periphery of the bottom cover outer wall 228 c canbe used as the operation portion, when the user chooses a location onthe bottom cover outer wall 228 c to apply the force, the opposite sideof this location can be regarded as the force support portion 228′.

Please refer to FIG. 56, a schematic perspective view of one embodimentof the present invention after the bottom cover is detached from thehousing, which only takes the protruding operating portion 228 as anexample, but the present invention is not limited to this. Theembodiments of FIGS. 50 to 53 are substantially the same after thebottom cover 20 has been opened. When the bottom cover 20 is separatedfrom the bottom opening 111′, it can be seen that the adhesive pad 52has an adhesive side, and below it is the lower mount base 50. A convexring 115 can be seen near the bottom opening 111′. The annular groove224 can be seen from the bottom cover opening 20′ of the bottom cover20, and the positioning piece 227 has also been disengaged from thematching portion 116. The user may then press the adhesive pad 52against the living body's skin surface P where the sensor 72 (referringto FIG. 49) and operate the housing 11 to achieve the effect ofdisposing the sensor.

Combine FIG. 56-57 and FIG. 58-61 schematic diagrams of an operationflow for assembling a physiological signal monitoring device on asurface of a living body, FIG. 58 shows a schematic diagram of a userholding the housing 11 and attaching the adhesive pad 52 toward thesurface P of the living body. In this illustration, the bottom of theimplantation module 30 towards to the skin. The activation mechanism ofthe implantation module 30 of the present invention has been describedabove, and thus there is no need to repeat. When the user applies a pushto the housing 11, the push moves the housing downward, renders thesensor module 70 be detached from the implantation module 30, and causesthe signal sensing end 721 of the sensor 72 to be implanted under theskin P of the living body. Please also refer to FIGS. 7-10 for theimplantation process.

FIG. 59 shows the step of removing the implantation device while leavingthe sensor module 70 on the surface P of the living body. In theaforementioned implantation process, the sensor module 70 has beenattached to the base 50 in advance, so the two can be regarded as oneitem.

FIG. 60 shows that after the aforementioned steps are completed, theuser places the transmitter 90 on the base 50 so that the signal outputend (sensor base 71) of the sensor 72 is electrically connected to theelectrical connection port 921 of the transmitter 90. The outer edge 95of the transmitter 90 and the inner edge 59 of the base 50 can becombined through a configuration match such as concave-convex fit. Theuser can find out the relative relationship between the configurationsof the transmitter 90 and the base 50 by taking advantage of thealignment portion 90′ of the sensor 90 and the alignment portion 50′ ofthe base 50. According to a preferred embodiment, the transmitter 90 isinserted into the base 50 in a vertical direction from above the base50.

Please refer to FIG. 61. After the physiological signal monitoringdevice 400 as described above is disposed on the body surface P, awireless communication between the sensor 90 and a user device 200loaded with application software, such as transmitting messages to eachother through a Bluetooth system, can be established. The physiologicalsignals (such as physical or chemical signals related to glucoseconcentration in the living body) sensed by the sensor 72 through thesignal sensing end 721 from the subcutaneous portion of the living bodycan be converted into voltage or current signals, which are interpretedand processed by the transmitter 90 and sent to the user device 200 viathe wireless communication. Commonly used user devices 200, such assmart phones, physiological signal transceiver or blood glucose metersloaded with appropriate application programs to show as well as analyzedata, can store the collected data to provide medical or home care unitsfor further applications.

FIGS. 62 and 63 show two other exemplary embodiments of the dry andairtight storage container of the present invention. The embodimentshown in FIG. 62 incorporates the features of the housing 11 and themain body cover 32 into the lining piece 12, while the embodiment shownin FIG. 63 incorporates the features of the housing 11 into the liningpiece 12 providing an accommodating space 14 to accommodate theimplantation module 30. When the sealing element 300 in the figure isdisposed at the bottom opening of the lining piece 12, an airtight spacecan be formed by the lining piece 12 and the sealing element 300 so thatthe device contained therein can be stored for a long period of time.

Thus, according to an embodiment of the present invention for assemblinga physiological signal monitoring device on a surface of a living body,referring to the embodiment shown in FIG. 62 and then referring to theprocess steps similar to those shown in FIGS. 56-61, it can beappreciated as the steps of: (a) detaching the sealing element 300 fromthe housing (lining piece 12) to expose the adhesive pad 52 from thebottom of the housing; (b) while holding the housing, causing theadhesive pad 52 to be attached to the body surface P; and (c) applying apressing force on the housing to cause the sensor module 70 to bedetached from the implantation module 30 and cause the signal sensingend 721 to be implanted under the body surface P. The subsequentassembly and operation steps are detailed in the previous sections, sothere is no need to repeat.

FIG. 64 shows another exemplary embodiment of the dry and airtightstorage container of the present invention. A sealing body 400 and thesealing member 300 are used to form an air-tight container providing theaccommodating space to accommodate the implantation device (not shown).Referring to the embodiment shown in FIG. 64 and then referring to theprocess steps similar to those shown in FIGS. 56-61, it can beappreciated as the following steps: (a) detaching the air-tightcontainer from the implanting device to expose the adhesive pad 52 froma bottom of the implanting device; (b) while holding the housing 11,causing the adhesive pad 52 to be attached to the body surface P; and(c) applying a pressing force on the housing 11 to cause the sensormodule 70 to be detached from the implantation module 30 and cause thesignal sensing end 721 to be implanted under the surface P of the livingbody. The subsequent assembly and operation steps are detailed in theprevious sections, so there is no need to repeat. The sealing body 400can be one of a blister, aluminum foil package and a desiccatingcontainer.

The operation process of the implantation device (the sensor carryingcontainer) of the present invention and the assembling method with thetransmitter further provide a user with a relatively fast and easyinstallation method to facilitate the user to quickly complete theassembling of physiology signal monitoring device on the body surface.

The main efficacy of the present invention are summarized as below:

First, in the desiccating and air-tight container of the presentinvention, the bottom cover is air-tightly combined with the housing, sothat the housing and the bottom cover form an air-tight space, and incombination with the setting of the desiccant, deliquescence of thechemical reagent on the sensor in the airtight space can be avoided,which ensures the detection accuracy of the sensor. In addition, adrying indication unit can also be added to the outside or inside of thehousing (preferably, the drying indication unit can be a dryingindication material), with a transparent or translucent portion on theopposite part of the housing, so that the user can identify whether thesensor has been wet by means of the drying indication unit. The mannerand location of the desiccant are not limited by the types disclosed inthe examples.

Second, the way of air-tight combination of the air-tight containeraccording to the present invention is through the joining method of theconvex ring and the ring groove. When the container is closed, themoisture absorption in the container is no more than 200 mg per day, orno more than 50 mg per day, or no more than 1 mg per day, or no morethan 0.5 mg per day, or no more than 0.3 mg per day, or not more than0.25 mg per day, and the container achieves a store condition at arelative humidity of 0-100% and a temperature of 0-45° C., or storageconditions with relative humidity of 0-100% and temperature of 0-40° C.,or storage conditions of relative humidity of 10-90% and temperature of4-30° C., and can be maintained for at least 2 years or at least 1 yearof effectiveness during storage with effects of good air-tightness, easyto open and resistance to negative pressure. The invention can alsoachieve the effect of air-tight bonding through the way of hardinterference.

Third, the detaching module of the present invention does not include atransmitter, and the transmitter and the sensor assembly are separatelyarranged to ensure that the electronic components in the transmitterwill not be damaged due to the high temperature or chemical environmentrequired by the sterilization process, so the production yield of thetransmitter can be improved.

Fourth, the implant module of the present invention mainly uses theelastic forces provided by the two pre-compressed elastic members tomake the implant module an automatic mechanism sequentially using thefirst and the second elastic members. The elastic forces for implantingand withdrawing needles are provided by the implant module, so there isno need to rely on the force from the user's hand to press down theneedle. It also has the effect of one-step pressing the housing assemblyto complete the automatic needle implantation as well as needlewithdrawal action. In other words, the present invention can greatlyimprove the operational certainty, and can effectively solve the problemof the prior art that the smoothness of the implanting and needleextraction can be affected due to the user's proficiency duringoperation.

Fifth, when the overall assembly of the desiccating and air-tightcontainer according to the present invention is completed and not yet inuse, the constraint portion formed by the abutting portion of the bottomcover and the engaging portion of the housing can avoid accidentalimplanting of the needle due to the container accidentally fallingduring transportation.

Sixth, the needle piece is extracted into a position between the needleimplanting seat and the auxiliary implantation seat to avoid beingexposed, which may achieve the effect of hiding the needle piece afteruse.

Seventh, the main cover compresses and accumulates the first elasticelement so that the first elastic element does not directly contact thecasing assembly. Therefore, the operator does not need to resist theelastic force from the first elastic element when the casing assembly ispressed down for the needle implantation operation, which renders theimplantation operation effortless.

Eighth, due to the restriction relationship formed by the auxiliaryimplantation seat and the main body before the needle is implanted, theleft-right deviation and pulling can be avoided when the needle isimplanted under the skin of the living body, which improves thestability of the needle stroke and reduces the pain of the living bodyor the patient.

Ninth, after the user presses the casing assembly by hand, theimplanting module is triggered and automatically uses the elastic forceprovided by the first and the second elastic elements to sequentiallyimplant and extract the needle, thereby completing the automatic needleimplanting and extracting time is no more than 100 ms, or no more than50 ms, or even less than 8 ms, 6 ms, 4 ms or 2 ms.

Tenth, in the assembly sequence of the components of the presentinvention, the first elastic element, the needle extracting mount, thesecond elastic element and the needle implanting seat are previouslyinstalled between the main cover and the main body, the needleimplanting piece is finally put on the auxiliary implantation seat andthe sensor assembly therebetween. The needle implanting piece is used tocouple to the needle extracting mount, whereby the sensor assembly andthe implant module forming a clutch design, which can not only greatlyimprove the assembly yield, but also effectively reduce the cost of thesensor assembly.

Eleventh, the sensor assembly of the present invention is pre-assembledwith the implanting module through the auxiliary implantation seat, andfinally the bottom cover is combined with the housing. In other words,the present invention does not require the operation of grasping thesensor assembly onto the lower base mount by the implanting module.

Twelfth, a protective ring can be sleeved on the bottom of the housingaccording to one embodiment of the present invention. The lower basemount is disposed on the inner side of the bottom edge of the protectivering before the implantation operation, so when the bottom edge of theprotective ring buts against the skin surface of the living body, thelower base mount will not contact the skin surface. The user can movethe implantation device to the position to be implanted, and thetriggering action of pressing down the casing assembly or the housing isperformed afterwards. Therefore, with the aid of the protective ring ofthis embodiment, it can be adjusted to the required position enforce theneedle implantation operation is performed, which is quite convenient touse.

Thirteenth, the outer side surface of the bottom cover has a forceapplying portion adjacent to the brim and protruding from the outer sidesurface. The existing of the force applying portion makes it easy forthe user to open and remove the bottom cover. Furthermore, the forceapplying portion is provided to control the opening force to no morethan 2 kilogram force (kgf), so that the container can be easily openedand is resistant to negative pressure, and can be quickly disassembledby the user with less effort. The matching between the positioning pieceand the matching portion provides the user with the function offoolproof alignment when operating to open and close the container.

Fourteenth, the bottom cover is equipped with a tearing element whichcan help to tear off the edge of the release layer of the self-adhesivepad, so as to achieve the effect of tearing off the release layer at thesame time as the bottom cover is opened, and so that the user does notneed to tear off the release layer with bare hands, thus reducing therisk of inaccurate sensing data due to contamination of the sensor, andalso avoids the problem of contaminated adhesive pad causing decreasedadhesive force.

Fifteenth, the operation process of the implantation device (the sensorcarrying container) of the present invention and the assembling methodwith the transmitter further provide a user with a relatively fast andeasy installation method to facilitate the user to quickly complete theassembling of physiology signal monitoring device on the body surface.

Through the foregoing embodiments, the storage device and method capableof maintaining a dry state provided by the present invention should be amajor innovation in technology field. Obviously, the apparatus andmethod of the present invention can achieve many effects that are hardto expect by prior arts.

While the invention has been described in terms of what is presentlyconsidered to be the most practical and preferred embodiments, it is tobe understood that the invention needs not be limited to the disclosedembodiments. On the contrary, it is intended to cover variousmodifications and similar arrangements included within the spirit andscope of the appended claims which are to be accorded with the broadestinterpretation so as to encompass all such modifications and similarstructures.

What is claimed is:
 1. A method for assembling a physiological signalmonitoring apparatus on a body surface of a living body, wherein thephysiological signal monitoring apparatus is used to measure aphysiological signal and includes a sensor module and a transmitter, thesensor module is configured to be disposed on the body surface by animplanting device, and the physiological signal monitoring apparatuscomprises: the sensor module including: a sensor measuring thephysiological signal, and having a signal sensing end and a signaloutput end; a base accommodating the sensor; and an adhesive paddisposed under the base, and configured to attach the base on the bodysurface; and the transmitter having a port for receiving thephysiological signal, wherein the implanting device includes: a housinghaving a bottom opening; an implantation module disposed in the housing,and bearing the sensor module; and a bottom cover detachably coupled tothe bottom opening, wherein the method comprises steps of: (a) detachingthe bottom cover from the housing to expose the sticker from the bottomopening; (b) while holding the housing, causing the adhesive pad to beattached to the body surface; (c) applying a pressing force on thehousing to cause the sensor module to be detached from the implantationmodule and the signal sensing end to be implanted under the bodysurface; (d) removing the implanting device while leaving the sensormodule on the body surface; and (e) placing the transmitter on the baseso that the signal output end is electrically connected to the port. 2.The method according to claim 1, wherein the step (c) is performed byapplying the pressing force to activate the implantation module torelease an operating force to cause the sensor module to be detachedfrom the implantation module and to dispose the sensor on the base. 3.The method according to claim 1, wherein the implanting device furtherincludes a needle implanting mechanism, a needle extraction module and aneedle implanting device configured to carry the sensor, the needleimplanting mechanism is configured to drive the needle implanting deviceto carry the sensor and implant the sensor under the skin of the livingbody, and the needle extraction module is configured to withdraw theneedle implanting device after the sensor is implanted.
 4. The methodaccording to claim 3, wherein the implantation module is configured toperform an automatic needle implantation and an automatic needlewithdrawal operation, and a time period for completing the automaticneedle implantation and the automatic needle withdrawal operation is nomore than 100 milliseconds.
 5. The method according to claim 1, whereinthe pressing force is applied on a surface of the housing opposite tothe bottom opening.
 6. The method according to claim 1, wherein thebottom opening has a convex ring disposed along an edge of the bottomopening, the bottom cover has an annular groove disposed along an edgeof the bottom cover, and the convex ring is fitted into the annulargroove, the bottom cover has a side wall adjacent to the bottom openingand an operating portion configured on the side wall to bear a force, asupporting portion is formed on the opposite end of the operatingportion, a distance between the operating portion and the supportingportion and the force form an operating moment thereby, and a sidedetachment is formed between the bottom cover and the housing and causesthe bottom cover to be detached from the housing.
 7. The methodaccording to claim 6, wherein the operating portion is a convex portionprotruding from an outer wall surface of the bottom cover.
 8. The sensorimplantation device according to claim 6, wherein the operating portionis a concave portion concaving from an outer wall surface of the bottomcover.
 9. The sensor implantation device according to claim 6, whereinthe operating portion is an outer side wall of the bottom cover.
 10. Themethod according to claim 6, wherein the step (a) further comprisessub-steps of: (a1) taking advantage of a stress concentration status tocause a partial side detachment between the bottom cover and thehousing; and (a2) continually applying the force on the operatingportion toward a direction away from the housing to enlarge the partialside detachment.
 11. The method according to claim 1, wherein the bottomopening has a first bevel structure disposed on a sidewall of the bottomopening, the bottom cover has a second bevel structure matching thefirst bevel structure, and the step (a) is performed by applying atorque on one of the housing and the bottom cover to detach the bottomfrom the housing.
 12. The method according to claim 1, wherein the basehas an inner edge, the transmitter has an outer edge configured to matchthe inner edge of the base so that the transmitter is configured to beplaced on the base from above the base.
 13. The method according toclaim 12, wherein in the step (e), the transmitter is placed on the basealong a vertical direction.
 14. The method according to claim 12,wherein the inner edge of the base and the outer edge of the transmittermatch in configuration.
 15. A method for assembling a physiologicalsignal monitoring apparatus on a body surface of a living body, whereinthe physiological signal monitoring apparatus is used to measure aphysiological signal and includes a sensor module and a transmitter, thesensor module is configured to be disposed on the body surface by animplanting device, and the physiological signal monitoring apparatuscomprises: the sensor module including: a sensor measuring thephysiological signal, and having a signal sensing end and a signaloutput end; a base accommodating the sensor; and an adhesive paddisposed connecting the base, and configured to attach the base on thebody surface; and the transmitter having a port for receiving thephysiological signal, wherein the implanting device includes: a housinghaving an accommodating space; an implantation module disposed in thehousing, and bearing the sensor module; and an air-tight containeraccommodating therein the implantation module and forming an air-tightspace, wherein the method comprises steps of: (a) detaching theair-tight container from the implanting device to expose the adhesivepad from a bottom of the implanting device; (b) while holding thehousing, causing the adhesive pad to be attached to the body surface;(c) applying a pressing force on the housing to cause the sensor moduleto be detached from the implantation module and cause the signal sensingend to be implanted under the body surface; (d) removing the implantingdevice while leaving the sensor module on the body surface; and (e)placing the transmitter on the base so that the signal output end iselectrically connected to the port of the transmitter.
 16. The methodaccording to claim 15, wherein the air-tight container is at least oneof a blister, an aluminum foil package, and a desiccating vial.
 17. Amethod for assembling a physiological signal monitoring apparatus on abody surface of a living body, wherein the physiological signalmonitoring apparatus is used to measure a physiological signal andincludes a sensor module and a transmitter, the sensor module isconfigured to be disposed on the body surface by an implanting device,and the physiological signal monitoring apparatus comprises: the sensormodule including: a sensor measuring the physiological signal, andhaving a signal sensing end and a signal output end; a baseaccommodating the sensor; and an adhesive pad disposed connecting thebase, for attaching the base on the body surface; and the transmitterhaving a port for receiving the physiological signal, wherein theimplanting device includes: a housing having an accommodating space; animplantation module disposed in the housing, and bearing the sensormodule; and a sealing element causing airtight the accommodating space,wherein the method comprises steps of: (a) detaching the sealing elementfrom the housing to expose the sticker from a bottom of the housing; (b)while holding the housing, causing the adhesive pad to be attached tothe body surface; (c) applying a pressing force on the housing to causethe sensor module to be detached from the implantation module and causethe signal sensing end to be implanted under the body surface; (d)removing the implanting device while leaving the sensor module on thebody surface; and (e) placing the transmitter on the base so that thesignal output end is electrically connected to the port.